VSIG4

Across TCGA patient cohorts, VSIG4 protein abundance is significantly associated with the RNA expression of many other genes, with 13,914 significant associations in total. GBM shows the largest number of these associations.

The most reproducible VSIG4-associated genes across cancer lineages are CYTH4, MS4A4A, and SIGLEC9. Each is linked with VSIG4 in more than 9 cancer types. Because this analysis shows association rather than direction, both VSIG4-to-partner and partner-to-VSIG4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VSIG4 versus CYTH4 in GBM, with a Pearson correlation of 0.72.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSIG4→partner) and Y-score (partner→VSIG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CYTH4 →	+1.106	+0.987	<.001	<.001	3	10
GBM	MS4A4A →	+1.687	+1.221	<.001	<.001	3	10
GBM	SIGLEC9 →	+1.303	+1.210	<.001	<.001	3	10
GBM	LAIR1 →	+1.401	+1.229	<.001	<.001	3	10
GBM	CD163 →	+2.417	+1.257	<.001	<.001	3	10
GBM	FCGR1B →	+0.760	+0.917	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,914 associations by consensus.

VSIG4 vs CYTH4 — GBM

Explore this scatter interactively →