VSIG4

Across TCGA patient cohorts, VSIG4 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VSIG4-associated genes across cancer lineages are 4E-BP1, FoxM1, and ACC1. Each is linked with VSIG4 in more than 2 cancer types. Because this analysis shows association rather than direction, both VSIG4-to-partner and partner-to-VSIG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by VSIG4-low versus VSIG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSIG4→partner) and Y-score (partner→VSIG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.216	+1.614	.012	.020	3	3
UCEC	FoxM1 →	+0.175	+2.321	.034	.033	3	2
UCEC	ACC1 →	+0.298	+3.598	.010	.001	3	2
UCEC	PDCD4 →	-0.517	-3.807	<.001	<.001	3	2
UCEC	eIF4G →	+0.203	+2.115	.040	.016	3	1
UCEC	Ku80 →	+0.162	+1.425	.032	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

4E-BP1 by VSIG4 expression — UCEC

Explore this box plot interactively →