VSIG2

Across TCGA patient cohorts, VSIG2 protein abundance is significantly associated with the protein abundance of many other proteins, with 13,200 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible VSIG2-associated proteins across cancer lineages are VSIG2_S312, VWA5A, and IQGAP2. Each is linked with VSIG2 in more than 3 cancer types. Because this analysis shows association rather than direction, both VSIG2-to-partner and partner-to-VSIG2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VSIG2 versus VSIG2_S312 in PDAC, with a Pearson correlation of 0.72.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (VSIG2→partner) and Y-score (partner→VSIG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	VSIG2_S312 →	+1.849	+1.327	<.001	<.001	3	4
LUAD	VWA5A →	+0.548	+1.038	<.001	<.001	3	4
LSCC	IQGAP2 →	+0.447	+1.282	<.001	<.001	3	4
LUAD	IQGAP2_S16 →	+0.801	+1.067	<.001	<.001	3	4
LUAD	KIF13B →	+0.365	+0.766	<.001	.001	3	4
COAD	MLPH →	+1.047	+1.037	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,200 associations by consensus.

VSIG2 vs VSIG2_S312 — PDAC

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