VSIG2

Across TCGA patient cohorts, VSIG2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VSIG2-associated genes across cancer lineages are Src_pY527, 4E-BP1_pT37_T46, and C-Raf_pS338. Each is linked with VSIG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VSIG2-to-partner and partner-to-VSIG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by VSIG2-low versus VSIG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSIG2→partner) and Y-score (partner→VSIG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY527 →	-0.596	-2.990	.011	.036	3	2
UCEC	4E-BP1_pT37_T46 →	-0.635	-3.169	.002	.020	3	2
UCEC	C-Raf_pS338 →	-0.135	-3.169	.002	.020	3	2
UCEC	mTOR_pS2448 →	-0.186	-3.169	.022	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.650	-3.000	.008	.036	3	1
UCEC	PKC-b-II_pS660 →	-0.325	-3.169	.032	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Src_pY527 by VSIG2 expression — UCEC

Explore this box plot interactively →