Across TCGA pan-cancer cohorts, VSIG10L RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of VSIG10L’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where VSIG10L RNA is repressed in tumor relative to normal tissue. In most cancer types VSIG10L is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.
HNSC, KIRP, and LUAD are the cancer types where VSIG10L tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VSIG10L RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.