VSIG10

Across TCGA patient cohorts, VSIG10 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VSIG10-associated genes across cancer lineages are PDCD4, PDK1_pS241, and VHL. Each is linked with VSIG10 in more than 1 cancer types. Because this analysis shows association rather than direction, both VSIG10-to-partner and partner-to-VSIG10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by VSIG10-low versus VSIG10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSIG10→partner) and Y-score (partner→VSIG10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.549	-2.459	.015	.020	3	1
UCEC	PDK1_pS241 →	+0.174	+3.000	.035	.036	3	1
UCEC	VHL →	-1.094	-3.169	<.001	.019	3	1
SKCM	Mre11 →	-0.176	-3.169	.026	.019	3	1
UCEC	AMPK_pT172 →	+0.487	+3.000	.014	.036	2	1
UCEC	Chk2_pT68 →	-0.185	-2.459	.040	.020	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PDCD4 by VSIG10 expression — UCEC

Explore this box plot interactively →