VSIG1

Across TCGA pan-cancer cohorts, VSIG1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated VSIG1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher VSIG1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated VSIG1 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC, LSCC, and LUAD are the cancer types where VSIG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.713	0.414	<.001	63	view →
LSCC	DFS	Quartile	All	0.356	0.877	.033	4	view →
LUAD	OS	Tertile	II,III,IV	0.350	0.822	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

VSIG1–PDAC (OS)

Open the PDAC breakdown →