VSIG1

Across TCGA patient cohorts, VSIG1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VSIG1-associated genes across cancer lineages are EGFR_pY1068, Notch1, and STAT5a. Each is linked with VSIG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VSIG1-to-partner and partner-to-VSIG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by VSIG1-low versus VSIG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VSIG1→partner) and Y-score (partner→VSIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.236	-3.584	.010	.002	3	2
UCEC	Notch1 →	+0.151	+1.502	.003	.030	3	2
UCEC	STAT5a →	+0.351	+2.321	.016	.033	3	2
UCEC	ATM →	-0.403	-2.247	.015	.001	3	2
UCEC	14-3-3_beta →	-0.084	-2.295	.022	.033	3	1
UCEC	eIF4E →	+0.217	+2.807	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

EGFR_pY1068 by VSIG1 expression — UCEC

Explore this box plot interactively →