VRTN

Across TCGA patient cohorts, VRTN RNA expression is significantly associated with the go_rna of many other GO terms, with 6,703 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible VRTN-associated GO terms across cancer lineages are Regulation of DNA recombination, Ribosomal large subunit biogenesis, and DNA-templated transcription elongation. Each is linked with VRTN in more than 15 cancer types. Because this analysis shows association rather than direction, both VRTN-to-partner and partner-to-VRTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA recombination grouped by VRTN-low versus VRTN-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VRTN→partner) and Y-score (partner→VRTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of DNA recombination →	+0.042	+0.319	<.001	<.001	3	16
STAD	Ribosomal large subunit biogenesis →	+0.041	+0.339	<.001	<.001	3	16
STAD	DNA-templated transcription elongation →	+0.055	+0.329	<.001	<.001	2	16
STAD	Nucleus organization →	+0.056	+0.380	<.001	.005	2	16
ESCA	Nuclear envelope organization →	+0.055	+0.394	.001	.001	2	16
STAD	Methylation →	+0.049	+0.390	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,703 associations by consensus.

Regulation of DNA recombination by VRTN expression — ESCA

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