VRTN

Across TCGA patient cohorts, VRTN mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VRTN-associated genes across cancer lineages are ATM, Annexin-1, and p53. Each is linked with VRTN in more than 3 cancer types. Because this analysis shows association rather than direction, both VRTN-to-partner and partner-to-VRTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by VRTN-low versus VRTN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VRTN→partner) and Y-score (partner→VRTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.349	-2.571	.024	.010	3	4
SKCM	Annexin-1 →	+0.570	+1.906	<.001	.014	3	3
COAD	p53 →	-0.403	-3.000	.002	.035	3	3
UCEC	Shc_pY317 →	-0.200	-3.169	<.001	<.001	3	3
UCEC	GAPDH →	+0.506	+2.115	.005	.016	3	3
UCEC	TFRC →	+0.492	+2.459	.006	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

ATM by VRTN expression — UCEC

Explore this box plot interactively →