VRTN

Across TCGA cell cohorts, VRTN mutation is significantly associated with the RNA expression of many other genes, with 112 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VRTN-associated genes across cancer lineages are BHLHE23, MYL7, and UCMA. Each is linked with VRTN in more than 1 cancer types. Because this analysis shows association rather than direction, both VRTN-to-partner and partner-to-VRTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BHLHE23 grouped by VRTN-low versus VRTN-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VRTN→partner) and Y-score (partner→VRTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	BHLHE23 →	+0.032	+4.357	<.001	.006	3	2
BLOOD_Leukemia	MYL7 →	+0.056	+3.339	.001	.006	3	1
BLOOD_Leukemia	UCMA →	+0.074	+3.926	<.001	.003	3	1
BLOOD_Leukemia	CDH16 →	+0.018	+4.442	.005	.004	3	1
BLOOD_Leukemia	SFT2D3 →	+0.591	+3.450	<.001	.004	3	1
BLOOD_Leukemia	TBPL2 →	+0.118	+4.366	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 112 associations by consensus.

BHLHE23 by VRTN expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →