VRK3

Across TCGA pan-cancer cohorts, VRK3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated VRK3 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher VRK3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated VRK3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, GBM, and UCEC are the cancer types where VRK3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	1.000	0.452	<.001	25	view →
GBM	OS	Median	All	0.898	0.731	.009	11	view →
UCEC	DFS	Median	All	0.847	0.952	.038	6	view →
HNSC	DFS	Median	III,IV	0.923	1.000	.022	5	view →
PDAC	DFS	Median	II,III,IV	0.838	0.672	.023	4	view →
LSCC	OS	Tertile	All	0.928	0.777	.011	2	view →
CCRCC	DFS	Median	III,IV	0.774	0.207	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

VRK3–LUAD (OS)

Open the LUAD breakdown →