VRK3

Across TCGA patient cohorts, VRK3 mutation is significantly associated with the RNA expression of many other genes, with 3,514 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VRK3-associated genes across cancer lineages are RFKP1, ZNHIT3, and PIGW. Each is linked with VRK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both VRK3-to-partner and partner-to-VRK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFKP1 grouped by VRK3-low versus VRK3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VRK3→partner) and Y-score (partner→VRK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RFKP1 →	+0.093	+4.683	.002	.005	3	2
UCEC	ZNHIT3 →	+0.459	+3.080	<.001	<.001	3	2
UCEC	PIGW →	+0.737	+3.069	<.001	<.001	3	2
HNSC	TRBV24OR9-2 →	+0.087	+4.736	.001	.007	3	2
UCEC	MYO19 →	+0.515	+2.201	<.001	<.001	3	2
UCEC	DHRS11 →	+0.484	+2.431	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,514 associations by consensus.

RFKP1 by VRK3 expression — BRCA

Explore this box plot interactively →