VRK3

Across TCGA cell cohorts, VRK3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VRK3-associated genes across cancer lineages are LCE3D, OR4F6, and GALP. Each is linked with VRK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both VRK3-to-partner and partner-to-VRK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE3D grouped by VRK3-low versus VRK3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VRK3→partner) and Y-score (partner→VRK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LCE3D →	+0.061	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR4F6 →	+0.018	+4.922	<.001	.009	3	1
BLOOD_Leukemia	GALP →	+0.027	+5.201	.005	.006	3	1
BLOOD_Leukemia	TCP10L3 →	+0.079	+4.922	<.001	.009	3	1
OVARY	PNLIPRP1 →	+0.031	+4.450	<.001	.004	3	1
OVARY	SCGB1D4 →	+0.097	+4.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

LCE3D by VRK3 expression — BLOOD_Leukemia

Explore this box plot interactively →