VRK2

Across TCGA pan-cancer cohorts, VRK2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VRK2 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher VRK2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated VRK2 expression acts as an unfavorable survival marker.

CCRCC, LUAD, and HNSC are the cancer types where VRK2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.602	0.987	.005	27	view →
LUAD	OS	Quartile	II,III,IV	0.261	0.687	.010	12	view →
HNSC	DFS	Median	All	0.698	1.000	.020	6	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VRK2–CCRCC (OS)

Open the CCRCC breakdown →