VRK2

Across TCGA patient cohorts, VRK2 protein abundance is significantly associated with the RNA expression of many other genes, with 8,335 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible VRK2-associated genes across cancer lineages are FANCL, SELENOI, and OLA1. Each is linked with VRK2 in more than 5 cancer types. Because this analysis shows association rather than direction, both VRK2-to-partner and partner-to-VRK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VRK2 versus FANCL in HNSC, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VRK2→partner) and Y-score (partner→VRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FANCL →	+0.757	+0.392	<.001	<.001	3	6
LSCC	SELENOI →	+0.663	+0.294	.001	<.001	3	5
HNSC	OLA1 →	+0.647	+0.323	.001	.001	3	5
LSCC	CKAP2L →	+0.884	+0.370	<.001	<.001	3	5
BRCA	KCMF1 →	+0.509	+0.376	<.001	<.001	3	5
HNSC	FAM136A →	+0.719	+0.272	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,335 associations by consensus.

VRK2 vs FANCL — HNSC

Explore this scatter interactively →