VRK2

Across TCGA patient cohorts, VRK2 mutation is significantly associated with the RNA expression of many other genes, with 3,480 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VRK2-associated genes across cancer lineages are MIR301A, MIR1207, and KIR3DL1. Each is linked with VRK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VRK2-to-partner and partner-to-VRK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR301A grouped by VRK2-low versus VRK2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VRK2→partner) and Y-score (partner→VRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR301A →	+0.337	+4.159	<.001	.002	3	2
SKCM	MIR1207 →	+0.352	+3.669	<.001	.006	3	2
COAD	KIR3DL1 →	+0.287	+3.652	<.001	.007	3	2
UCEC	LINC01727 →	+0.064	+1.844	<.001	<.001	3	2
UCEC	IGHD2-2 →	+1.342	+1.650	<.001	<.001	3	2
COAD	TRAJ12 →	+1.091	+3.140	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,480 associations by consensus.

MIR301A by VRK2 expression — SKCM

Explore this box plot interactively →