VRK2

Across TCGA patient cohorts, VRK2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VRK2-associated genes across cancer lineages are ASNS, ATM, and Caspase-7-cleavedD198. Each is linked with VRK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VRK2-to-partner and partner-to-VRK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by VRK2-low versus VRK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VRK2→partner) and Y-score (partner→VRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.397	+1.415	.001	.043	3	2
UCEC	ATM →	-0.483	-2.209	.001	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.935	+2.682	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.227	+2.459	.014	.018	3	2
UCEC	EGFR_pY1068 →	-0.213	-1.514	.012	.015	3	1
UCEC	eIF4E →	+0.217	+2.523	.002	<.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ASNS by VRK2 expression — UCEC

Explore this box plot interactively →