VRK2

Across TCGA cell cohorts, VRK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,754 significant associations in total. BONE shows the largest number of these associations.

The most reproducible VRK2-associated GO terms across cancer lineages are Protein localization to condensed chromosome, Regulation of DNA damage checkpoint, and Response to hepatocyte growth factor. Each is linked with VRK2 in more than 7 cancer types. Because this analysis shows association rather than direction, both VRK2-to-partner and partner-to-VRK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to condensed chromosome grouped by VRK2-low versus VRK2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VRK2→partner) and Y-score (partner→VRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Protein localization to condensed chromosome →	+0.109	+0.715	<.001	<.001	3	8
BREAST	Regulation of DNA damage checkpoint →	+0.078	+1.045	<.001	<.001	3	8
BONE	Response to hepatocyte growth factor →	+0.135	+0.876	<.001	.003	3	8
UPPER_AERODIGESTIVE_TRACT	Cellular response to hepatocyte growth factor stimulus →	+0.121	+0.749	.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Positive regulation of cell cycle process →	+0.065	+0.692	.009	.003	3	8
UPPER_AERODIGESTIVE_TRACT	DNA strand resection involved in replication fork processing →	+0.138	+0.764	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,754 associations by consensus.

Protein localization to condensed chromosome by VRK2 expression — LARGE_INTESTINE

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