VRK2

Across TCGA cell cohorts, VRK2 mutation is significantly associated with the RNA expression of many other genes, with 364 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VRK2-associated genes across cancer lineages are HHLA1, HSCB, and CBY1. Each is linked with VRK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both VRK2-to-partner and partner-to-VRK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HHLA1 grouped by VRK2-low versus VRK2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VRK2→partner) and Y-score (partner→VRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HHLA1 →	+0.011	+4.551	<.001	.004	3	1
LARGE_INTESTINE	HSCB →	+0.599	+3.212	.003	.006	3	1
LARGE_INTESTINE	CBY1 →	+0.549	+3.299	.007	.004	3	1
LARGE_INTESTINE	RASL10A →	+0.366	+3.212	<.001	.006	3	1
LARGE_INTESTINE	DTWD1 →	+0.699	+3.212	.001	.006	3	1
LARGE_INTESTINE	ASPN →	+0.043	+2.841	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 364 associations by consensus.

HHLA1 by VRK2 expression — BLOOD_Leukemia

Explore this box plot interactively →