VRK2

Across TCGA cell cohorts, VRK2 mutation is significantly associated with the mutation status of many other genes, with 3,498 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VRK2-associated genes across cancer lineages are PLEKHA7, TNC, and PHTF2. Each is linked with VRK2 in more than 3 cancer types. Because this analysis shows association rather than direction, both VRK2-to-partner and partner-to-VRK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLEKHA7 grouped by VRK2-low versus VRK2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VRK2→partner) and Y-score (partner→VRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PLEKHA7 →	+4.187	+5.000	.008	.008	1	4
SOFT_TISSUE	TNC →	+4.502	+5.066	.007	.007	1	4
OVARY	PHTF2 →	+4.977	+4.415	.007	.007	1	3
OVARY	JARID2 →	+2.754	+4.095	.009	.009	1	3
LUNG_NSCLC_LUAD	USP35 →	+4.187	+5.000	.008	.008	1	3
LUNG_NSCLC_LUAD	MYCN →	+5.772	+5.772	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,498 associations by consensus.

PLEKHA7 by VRK2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →