VRK1

Across TCGA pan-cancer cohorts, VRK1 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of VRK1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where VRK1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types VRK1 is over-expressed in tumor.

COAD, LSCC, and HNSC are the cancer types where VRK1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VRK1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.628	<.001	11	view →
LSCC	Male	III,IV	+0.967	<.001	8	view →
HNSC	All	IV	+0.621	<.001	8	view →
LUAD	Male	III,IV	+0.500	<.001	7	view →
PDAC	All	All	+0.235	.001	4	view →
CCRCC	Male	All	+0.105	.003	4	view →
OV	All	All	+0.653	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

VRK1–COAD

Open the COAD breakdown →