VPS9D1

Across TCGA patient cohorts, VPS9D1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS9D1-associated genes across cancer lineages are ASNS, eEF2, and EGFR_pY1068. Each is linked with VPS9D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS9D1-to-partner and partner-to-VPS9D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by VPS9D1-low versus VPS9D1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS9D1→partner) and Y-score (partner→VPS9D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.300	+2.000	.018	.030	3	2
UCEC	eEF2 →	+0.266	+2.321	.035	.033	3	1
UCEC	EGFR_pY1068 →	-0.250	-1.906	.004	.015	3	1
UCEC	eIF4E →	+0.206	+2.906	.005	.001	3	1
UCEC	A-Raf_pS299 →	-0.184	-2.392	<.001	<.001	3	1
UCEC	ERK2 →	+0.234	+3.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ASNS by VPS9D1 expression — UCEC

Explore this box plot interactively →