VPS8

Across TCGA pan-cancer cohorts, VPS8 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated VPS8 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher VPS8 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated VPS8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where VPS8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.942	0.759	.021	20	view →
CCRCC	DFS	Quartile	All	0.617	0.884	.014	16	view →
LSCC	OS	Median	III,IV	0.478	0.923	.003	9	view →
UCEC	DFS	Median	All	0.912	0.795	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

VPS8–HNSC (OS)

Open the HNSC breakdown →