VPS8

Across TCGA patient cohorts, VPS8 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS8-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and Stathmin. Each is linked with VPS8 in more than 2 cancer types. Because this analysis shows association rather than direction, both VPS8-to-partner and partner-to-VPS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by VPS8-low versus VPS8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS8→partner) and Y-score (partner→VPS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.424	-1.473	.002	.006	3	3
UCEC	Caspase-7-cleavedD198 →	+0.409	+1.415	.024	.040	3	3
SKCM	Stathmin →	+0.202	+3.025	.023	.018	3	3
UCEC	FOXO3a_pS318_S321 →	-0.079	-1.492	.037	.027	3	2
UCEC	mTOR_pS2448 →	-0.148	-2.571	.001	<.001	3	2
UCEC	mTOR →	-0.133	-1.807	.007	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ATM by VPS8 expression — UCEC

Explore this box plot interactively →