VPS8

Across TCGA cell cohorts, VPS8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,528 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible VPS8-associated GO terms across cancer lineages are Negative regulation of macroautophagy, Protein targeting to vacuole, and Protein desumoylation. Each is linked with VPS8 in more than 16 cancer types. Because this analysis shows association rather than direction, both VPS8-to-partner and partner-to-VPS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of macroautophagy grouped by VPS8-low versus VPS8-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS8→partner) and Y-score (partner→VPS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of macroautophagy →	+0.071	+0.864	.009	<.001	2	17
OESOPHAGUS	Protein targeting to vacuole →	+0.104	+0.934	<.001	.002	3	15
LUNG_SCLC	Protein desumoylation →	+0.115	+0.746	<.001	<.001	3	15
BREAST	Vacuolar transport →	+0.061	+0.710	.001	.002	3	14
UPPER_AERODIGESTIVE_TRACT	Establishment of protein localization to vacuole →	+0.080	+0.539	<.001	.006	2	15
OESOPHAGUS	Golgi vesicle transport →	+0.076	+0.889	.007	.004	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,528 associations by consensus.

Negative regulation of macroautophagy by VPS8 expression — STOMACH

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