VPS8

Across TCGA cell cohorts, VPS8 mutation is significantly associated with the RNA expression of many other genes, with 88 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS8-associated genes across cancer lineages are TMEM95, SERPINA2, and HHLA1. Each is linked with VPS8 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS8-to-partner and partner-to-VPS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM95 grouped by VPS8-low versus VPS8-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS8→partner) and Y-score (partner→VPS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TMEM95 →	+0.036	+3.836	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	SERPINA2 →	+0.118	+3.906	<.001	.004	3	1
BLOOD_Leukemia	HHLA1 →	+0.006	+4.551	.002	.004	3	1
BLOOD_Leukemia	OR52E2 →	+0.027	+4.969	<.001	.003	3	1
LUNG_NSCLC_LUAD	FGF6 →	+0.244	+5.813	<.001	<.001	3	1
LUNG_NSCLC_LUAD	PRAMEF8 →	+0.015	+4.544	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

TMEM95 by VPS8 expression — OESOPHAGUS

Explore this box plot interactively →