VPS72

Across TCGA patient cohorts, VPS72 mutation is significantly associated with the RNA expression of many other genes, with 1,158 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS72-associated genes across cancer lineages are MIR3137, EI24, and HEATR3. Each is linked with VPS72 in more than 2 cancer types. Because this analysis shows association rather than direction, both VPS72-to-partner and partner-to-VPS72 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3137 grouped by VPS72-low versus VPS72-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS72→partner) and Y-score (partner→VPS72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR3137 →	+0.427	+4.539	<.001	.008	3	2
UCEC	EI24 →	+0.484	+3.000	.004	.001	3	2
UCEC	HEATR3 →	+0.508	+2.332	.002	.003	3	2
UCEC	CXCL13 →	+1.732	+2.321	<.001	.006	3	2
UCEC	CPT2 →	+0.518	+3.592	.003	.001	3	2
UCEC	PKN3 →	+0.830	+4.098	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,158 associations by consensus.

MIR3137 by VPS72 expression — CESC

Explore this box plot interactively →