VPS72

Across TCGA patient cohorts, VPS72 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS72-associated genes across cancer lineages are S6_pS240_S244, ERK2, and HER3_pY1289. Each is linked with VPS72 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS72-to-partner and partner-to-VPS72 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by VPS72-low versus VPS72-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS72→partner) and Y-score (partner→VPS72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	S6_pS240_S244 →	+0.420	+3.025	.040	.019	3	1
UCEC	ERK2 →	+0.174	+2.000	.045	.032	3	1
UCEC	HER3_pY1289 →	+0.081	+2.827	.038	.035	3	1
UCEC	JNK2 →	+0.237	+2.834	.008	.034	3	1
UCEC	Ku80 →	+0.266	+3.013	.012	.018	3	1
UCEC	p62 Lck ligand →	+0.301	+2.179	.040	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

S6_pS240_S244 by VPS72 expression — COAD

Explore this box plot interactively →