VPS72

Across TCGA cell cohorts, VPS72 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,704 significant associations in total. BONE shows the largest number of these associations.

The most reproducible VPS72-associated GO terms across cancer lineages are mRNA 3'-end processing, Positive regulation of ERK1 and ERK2 cascade, and Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Each is linked with VPS72 in more than 13 cancer types. Because this analysis shows association rather than direction, both VPS72-to-partner and partner-to-VPS72 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA 3'-end processing grouped by VPS72-low versus VPS72-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS72→partner) and Y-score (partner→VPS72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	mRNA 3'-end processing →	+0.087	+0.698	<.001	.002	3	14
STOMACH	Positive regulation of ERK1 and ERK2 cascade →	-0.083	-1.007	<.001	<.001	3	11
SKIN	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.149	+0.835	<.001	<.001	3	10
BREAST	Regulation of ERK1 and ERK2 cascade →	-0.060	-0.671	<.001	<.001	3	9
OVARY	Epigenetic regulation of gene expression →	+0.042	+0.521	<.001	<.001	3	9
SOFT_TISSUE	G1/S transition of mitotic cell cycle →	+0.090	+0.845	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,704 associations by consensus.

mRNA 3'-end processing by VPS72 expression — SOFT_TISSUE

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