VPS72

Across TCGA cell cohorts, VPS72 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS72-associated genes across cancer lineages are SLC35G4 and SMIM23. Each is linked with VPS72 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS72-to-partner and partner-to-VPS72 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC35G4 grouped by VPS72-low versus VPS72-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS72→partner) and Y-score (partner→VPS72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC35G4 →	+0.014	+4.437	<.001	.004	3	1
BLOOD_Leukemia	SMIM23 →	+0.030	+6.569	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

SLC35G4 by VPS72 expression — LARGE_INTESTINE

Explore this box plot interactively →