Across TCGA pan-cancer cohorts, VPS52 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VPS52 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher VPS52 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated VPS52 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where VPS52 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.974	0.854	.005	37	view →
PDAC	OS	Median	IV	0.381	0.951	.006	14	view →
HNSC	OS	Median	II,III,IV	1.000	0.955	.027	3	view →
UCEC	DFS	Median	All	0.956	0.852	.023	2	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.750	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: VPS52 tumor-vs-normal RNA expression · all VPS52 data types