Across TCGA patient cohorts, VPS52 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS52-associated genes across cancer lineages are ATM, Bak, and Caspase-7-cleavedD198. Each is linked with VPS52 in more than 2 cancer types. Because this analysis shows association rather than direction, both VPS52-to-partner and partner-to-VPS52 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS52→partner) and Y-score (partner→VPS52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.538	-1.925	<.001	.005	3	3
UCEC	Bak →	+0.193	+1.807	.032	.025	3	2
UCEC	Caspase-7-cleavedD198 →	+0.496	+2.135	.020	.010	3	2
UCEC	EGFR_pY1068 →	-0.219	-1.584	.015	.019	3	1
UCEC	A-Raf_pS299 →	-0.121	-2.115	.004	.017	3	1
UCEC	Gab2 →	+0.317	+1.925	.013	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

VPS52 survival (RNA) · tumor vs normal (RNA) · all VPS52 data types