VPS50

Across TCGA pan-cancer cohorts, VPS50 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VPS50 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher VPS50 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated VPS50 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

CCRCC, LUAD, and COAD are the cancer types where VPS50 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	1.000	0.846	.014	21	view →
LUAD	DFS	Quartile	All	0.328	0.929	.002	16	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
PDAC	DFS	Quartile	III,IV	0.629	0.246	.034	4	view →
UCEC	DFS	Tertile	All	0.944	0.781	.017	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VPS50–CCRCC (DFS)

Open the CCRCC breakdown →