VPS50

Across TCGA patient cohorts, VPS50 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS50-associated genes across cancer lineages are C-Raf, CDK1, and ATM. Each is linked with VPS50 in more than 3 cancer types. Because this analysis shows association rather than direction, both VPS50-to-partner and partner-to-VPS50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by VPS50-low versus VPS50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS50→partner) and Y-score (partner→VPS50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.127	+1.392	.002	.017	3	4
SKCM	CDK1 →	+0.325	+3.169	<.001	.018	3	3
UCEC	ATM →	-0.551	-2.137	<.001	<.001	3	3
UCEC	FoxM1 →	+0.190	+1.637	.012	.001	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.374	-1.440	.004	.022	3	3
UCEC	Bap1-c-4 →	+0.140	+1.700	.030	.040	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

C-Raf by VPS50 expression — UCEC

Explore this box plot interactively →