VPS50

Across TCGA cell cohorts, VPS50 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,275 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VPS50-associated GO terms across cancer lineages are Protein targeting to vacuole, Establishment of protein localization to vacuole, and Protein localization to vacuole. Each is linked with VPS50 in more than 14 cancer types. Because this analysis shows association rather than direction, both VPS50-to-partner and partner-to-VPS50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein targeting to vacuole grouped by VPS50-low versus VPS50-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS50→partner) and Y-score (partner→VPS50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Protein targeting to vacuole →	+0.101	+0.788	.002	<.001	3	14
STOMACH	Establishment of protein localization to vacuole →	+0.083	+0.606	.002	.004	2	15
STOMACH	Protein localization to vacuole →	+0.087	+0.793	.005	<.001	2	14
CNS	Vesicle-mediated transport to the plasma membrane →	+0.057	+0.674	<.001	<.001	3	12
LUNG_NSCLC_LUAD	Endosomal transport →	+0.048	+0.628	<.001	<.001	3	12
PANCREAS	Endocytic recycling →	+0.057	+0.603	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,275 associations by consensus.

Protein targeting to vacuole by VPS50 expression — STOMACH

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