VPS50

Across TCGA cell cohorts, VPS50 mutation is significantly associated with the RNA expression of many other genes, with 305 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS50-associated genes across cancer lineages are KRTAP10-6, SNU13, and COCH. Each is linked with VPS50 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS50-to-partner and partner-to-VPS50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-6 grouped by VPS50-low versus VPS50-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS50→partner) and Y-score (partner→VPS50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRTAP10-6 →	+0.022	+4.867	<.001	.009	3	2
LARGE_INTESTINE	SNU13 →	+0.472	+3.743	.001	<.001	3	1
LARGE_INTESTINE	COCH →	+2.116	+3.169	<.001	.006	3	1
LARGE_INTESTINE	AHSA1 →	+0.542	+3.523	<.001	<.001	3	1
LARGE_INTESTINE	PIM2 →	+0.510	+2.628	.001	.002	3	1
LARGE_INTESTINE	ZNF419 →	-0.782	-2.455	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 305 associations by consensus.

KRTAP10-6 by VPS50 expression — BLOOD_Lymphoma

Explore this box plot interactively →