VPS4B

Across TCGA pan-cancer cohorts, VPS4B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated VPS4B data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher VPS4B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated VPS4B expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where VPS4B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	1.000	0.449	.023	8	view →
UCEC	DFS	Median	All	0.971	0.842	.006	8	view →
PDAC	DFS	Tertile	III,IV	0.786	0.515	.034	4	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	3	view →
GBM	OS	Median	All	0.429	0.623	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

VPS4B–HNSC (OS)

Open the HNSC breakdown →