VPS4B

Across TCGA patient cohorts, VPS4B mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS4B-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and FoxM1. Each is linked with VPS4B in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS4B-to-partner and partner-to-VPS4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by VPS4B-low versus VPS4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS4B→partner) and Y-score (partner→VPS4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.267	-2.321	.008	.034	3	1
UCEC	A-Raf_pS299 →	-0.155	-1.906	.001	.016	3	1
UCEC	FoxM1 →	+0.214	+1.906	.040	.016	3	1
UCEC	ACC_pS79 →	+0.361	+2.415	.009	.003	3	1
UCEC	Heregulin →	-0.143	-2.308	.003	.033	3	1
UCEC	HSP70 →	-0.356	-1.990	.027	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

EGFR_pY1068 by VPS4B expression — UCEC

Explore this box plot interactively →