VPS4B

Across TCGA cell cohorts, VPS4B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,287 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible VPS4B-associated GO terms across cancer lineages are ESCRT complex disassembly, ESCRT III complex disassembly, and Regulation of mitotic spindle assembly. Each is linked with VPS4B in more than 16 cancer types. Because this analysis shows association rather than direction, both VPS4B-to-partner and partner-to-VPS4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ESCRT complex disassembly grouped by VPS4B-low versus VPS4B-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS4B→partner) and Y-score (partner→VPS4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ESCRT complex disassembly →	+0.161	+1.036	<.001	<.001	3	17
SOFT_TISSUE	ESCRT III complex disassembly →	+0.161	+1.036	<.001	<.001	3	17
LIVER	Regulation of mitotic spindle assembly →	+0.094	+0.767	.002	.003	3	15
LUNG_SCLC	Late endosome to lysosome transport →	+0.131	+0.875	<.001	<.001	3	15
LUNG_SCLC	Negative regulation of exosomal secretion →	+0.238	+1.106	<.001	<.001	3	15
LIVER	Non-lytic viral release →	+0.145	+0.778	.001	.006	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,287 associations by consensus.

ESCRT complex disassembly by VPS4B expression — SOFT_TISSUE

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