VPS4B

Across TCGA cell cohorts, VPS4B mutation is significantly associated with the drug of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS4B-associated genes across cancer lineages are TL-2-105, SU11274, and CD532. Each is linked with VPS4B in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS4B-to-partner and partner-to-VPS4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TL-2-105 grouped by VPS4B-low versus VPS4B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS4B→partner) and Y-score (partner→VPS4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TL-2-105 →	+0.399	+2.652	.043	.045	2	1
LARGE_INTESTINE	SU11274 →	+0.436	+2.652	.036	.045	1	1
LARGE_INTESTINE	CD532 →	+0.461	+2.652	.021	.045	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TL-2-105 by VPS4B expression — LARGE_INTESTINE

Explore this box plot interactively →