VPS4A

Across TCGA pan-cancer cohorts, VPS4A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated VPS4A data layer compared with 19 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher VPS4A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated VPS4A expression acts as an unfavorable survival marker.

LUAD, ACC, and SARC are the cancer types where VPS4A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.147	0.812	<.001	36	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
SARC	DFS	Median	All	0.196	0.638	.004	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

VPS4A–LUAD (OS)

Open the LUAD breakdown →