VPS4A

Across TCGA patient cohorts, VPS4A protein abundance is significantly associated with the RNA expression of many other genes, with 6,439 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible VPS4A-associated genes across cancer lineages are IST1, TERF2, and TANGO6. Each is linked with VPS4A in more than 5 cancer types. Because this analysis shows association rather than direction, both VPS4A-to-partner and partner-to-VPS4A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VPS4A versus IST1 in OV, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS4A→partner) and Y-score (partner→VPS4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IST1 →	+0.494	+0.337	<.001	.004	3	6
HNSC	TERF2 →	+0.504	+0.471	.001	<.001	3	6
UCEC	TANGO6 →	+0.562	+0.215	.003	.005	2	6
OV	DHODH →	+0.663	+0.399	<.001	.002	3	4
OV	CYB5B →	+0.849	+0.505	<.001	<.001	3	4
CCRCC	UTP4 →	+0.528	+0.166	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,439 associations by consensus.

VPS4A vs IST1 — OV

Explore this scatter interactively →