VPS4A

Across TCGA patient cohorts, VPS4A mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS4A-associated genes across cancer lineages are C-Raf, eIF4E, and FoxM1. Each is linked with VPS4A in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS4A-to-partner and partner-to-VPS4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by VPS4A-low versus VPS4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS4A→partner) and Y-score (partner→VPS4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.242	+2.700	<.001	.006	3	2
UCEC	eIF4E →	+0.226	+2.335	.014	.018	3	1
UCEC	FoxM1 →	+0.345	+3.331	.002	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.111	-3.169	.042	.018	3	1
UCEC	ACC1 →	+0.361	+2.183	.023	.033	3	1
UCEC	JNK_pT183_Y185 →	-0.206	-2.794	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

C-Raf by VPS4A expression — UCEC

Explore this box plot interactively →