VPS4A

Across TCGA cell cohorts, VPS4A mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS4A-associated genes across cancer lineages are ZNF831, TAFA1, and CENPVL1. Each is linked with VPS4A in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS4A-to-partner and partner-to-VPS4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF831 grouped by VPS4A-low versus VPS4A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS4A→partner) and Y-score (partner→VPS4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF831 →	+0.018	+4.273	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.410	+4.273	<.001	.006	3	1
LARGE_INTESTINE	CENPVL1 →	+0.227	+4.095	<.001	.009	3	1
STOMACH	SKOR2 →	+0.023	+5.285	<.001	.003	3	1
STOMACH	PRAMEF4 →	+0.006	+5.285	<.001	.003	3	1
STOMACH	KRTAP4-2 →	+0.109	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ZNF831 by VPS4A expression — LARGE_INTESTINE

Explore this box plot interactively →