VPS45

Across TCGA pan-cancer cohorts, VPS45 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated VPS45 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher VPS45 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated VPS45 expression acts as an unfavorable survival marker.

ESCA, SKCM, and UCEC are the cancer types where VPS45 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	All	0.075	0.504	<.001	12	view →
SKCM	OS	Median	All	0.245	0.781	.008	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
GBM	DFS	Median	All	0.031	0.243	<.001	3	view →
LUSC	OS	Median	All	0.192	0.724	.040	3	view →
LUAD	OS	Median	II,III,IV	0.307	0.748	.046	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

VPS45–ESCA (DFS)

Open the ESCA breakdown →