VPS45

Across TCGA patient cohorts, VPS45 protein abundance is significantly associated with the RNA expression of many other genes, with 9,665 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible VPS45-associated genes across cancer lineages are RAB22A, FAM8A1, and SHISA4. Each is linked with VPS45 in more than 3 cancer types. Because this analysis shows association rather than direction, both VPS45-to-partner and partner-to-VPS45 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VPS45 versus RAB22A in BRCA, with a Pearson correlation of 0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS45→partner) and Y-score (partner→VPS45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RAB22A →	+0.375	+0.171	.002	<.001	3	4
LUAD	FAM8A1 →	+0.479	+0.196	<.001	.002	3	4
LUAD	SHISA4 →	+0.665	+0.191	<.001	<.001	3	4
LUAD	ARNTL2 →	-1.050	-0.208	<.001	<.001	3	4
LSCC	ATP9A →	+0.807	+0.168	<.001	.002	3	4
LSCC	RAB9B →	+0.662	+0.224	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,665 associations by consensus.

VPS45 vs RAB22A — BRCA

Explore this scatter interactively →