VPS45

Across TCGA patient cohorts, VPS45 mutation is significantly associated with the RNA expression of many other genes, with 2,217 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS45-associated genes across cancer lineages are RNA5SP86, PRELID3BP2, and RN7SKP263. Each is linked with VPS45 in more than 3 cancer types. Because this analysis shows association rather than direction, both VPS45-to-partner and partner-to-VPS45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP86 grouped by VPS45-low versus VPS45-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS45→partner) and Y-score (partner→VPS45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNA5SP86 →	+0.971	+5.142	<.001	.002	3	4
SKCM	PRELID3BP2 →	+0.126	+6.073	<.001	<.001	3	3
CESC	RN7SKP263 →	+0.166	+6.569	<.001	.001	3	2
UCEC	RNA5SP412 →	+0.629	+2.074	<.001	.004	3	2
BRCA	ST6GALNAC2P1 →	+0.044	+5.786	.008	.001	3	2
SKCM	RNU2-36P →	+0.140	+3.625	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,217 associations by consensus.

RNA5SP86 by VPS45 expression — COAD

Explore this box plot interactively →