VPS45

Across TCGA cell cohorts, VPS45 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible VPS45-associated genes across cancer lineages are OR4F6, TRIM49C, and ACSM5. Each is linked with VPS45 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS45-to-partner and partner-to-VPS45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F6 grouped by VPS45-low versus VPS45-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS45→partner) and Y-score (partner→VPS45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR4F6 →	+0.013	+5.087	<.001	.004	3	1
URINARY_TRACT	TRIM49C →	+0.006	+5.087	<.001	.004	3	1
LARGE_INTESTINE	ACSM5 →	+0.081	+3.141	<.001	.002	3	1
LARGE_INTESTINE	FAM205A →	+0.024	+3.444	<.001	.001	3	1
LARGE_INTESTINE	TECRL →	+0.011	+3.240	<.001	.004	3	1
LARGE_INTESTINE	LINGO4 →	+0.133	+3.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR4F6 by VPS45 expression — URINARY_TRACT

Explore this box plot interactively →