VPS39

Across TCGA patient cohorts, VPS39 mutation is significantly associated with the RNA expression of many other genes, with 3,474 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS39-associated genes across cancer lineages are PTGES2, VAC14, and MFN2. Each is linked with VPS39 in more than 3 cancer types. Because this analysis shows association rather than direction, both VPS39-to-partner and partner-to-VPS39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTGES2 grouped by VPS39-low versus VPS39-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS39→partner) and Y-score (partner→VPS39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PTGES2 →	+0.342	+3.859	.006	<.001	3	4
UCEC	VAC14 →	+0.560	+1.925	<.001	<.001	3	3
UCEC	MFN2 →	+0.451	+2.290	<.001	<.001	3	3
UCEC	MRPS15 →	+0.336	+1.949	.002	.008	3	3
UCEC	MRPS2 →	+0.399	+2.425	.001	.001	3	3
UCEC	PKMYT1 →	+0.687	+1.903	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,474 associations by consensus.

PTGES2 by VPS39 expression — UCEC

Explore this box plot interactively →